Temperature HS oven, 120 °C; valve/loop, 120 °C; transfer line, 120 °C Time Vial equilibration: 120 minutes for PS powder, 30 minutes for standard, inject time, 0.5 minute Vial 20-mL HS vial; vial shaking setting, 9; vial pressurize from 15 psi to 10 psi at 20 psi/min by a filling flow 50 mL/min Extraction mode Multiple; 12 times per vial
It is important to ensure the correct vial and cap are used! Vial Size: Headspace vials are available in 6, 10 and 20 ml sizes. Use a vial large enough to ensure adequate headspace or phase ratio without excessive dilution of the components of interest. Phase ratio is discussed later and should normally be at least 50 % of the sample volume.
Headspace analysis permits the detection of volatile substances in a liquid or solid sample and minimizes column contamination. A small volume of the sample is placed in a vial sealed with a septum and the sample vial is equilibrated at an appropriate elevated temperature.
Feb 22, 2023 · In the process of manufacture and transportation, vials are prone to breakage and cracks. Oxygen (O2) in the air entering vials can lead to the deterioration of medicine and a reduction in pesticide effects, threatening the life of patients. Therefore, accurate measurement of the headspace O2 concentration for vials is crucial to ensure pharmaceutical quality. In this invited paper, a novel
HOA measures the absorption of a laser light with a wavelength of 762 nm that passes through the gaseous headspace of a vial containing the freeze-dried drug product. The oxygen content in the headspace is determined by using a calibration curve from standards of known oxygen concentrations.
LIGHTHOUSE headspace analysis can be used in a variety of ways to detect a leaking container. Our oxygen ingress test method makes rapid, non-destructive oxygen measurements to determine the amount of air that has leaked into a container through a closure defect. Stopper "Pop-Up" effects on CCI of Freeze Dried Vials FMS-Oxygen Headspace Analyzer
Nominal Specifications Measurement Range: 0 – 25% Oxygen Measurement Time: 1 second Physical and Electrical Dimensions (WxDxH): 30.5 x 30.5 x 29.2 cm (12” x 12” x 11.5”) Weight: 13.6 kg (30 lbs) FMS Software Package Data Integrity and Compliance
Headspace vial caps are available in a variety of materials including aluminum, bimetal, and steel; headspace vial cap septa are available in PTFE/silicone, molded PTFE/butyl, and high-temperature varieties. Our headspace vial caps come in either 11 mm, 18 mm, 20 mm or 22 mm sizes. Most used headspace vial caps are crimp cap style.
Headspace vials often come in larger volumes than the 2-mL vials used in many liquid sampling systems. Common offerings are 10-mL, 20-mL and 22-mL capacities. Larger vials accommodate larger sample volume and/or a larger headspace above that sample.
Aug 2, 2022 · Different Types of Headspace Sampling . There are a few different types of headspace sampling, the first being the simplest: Syringe Injection. This is where a gas-tight syringe is used to withdraw a small volume of vapor from the headspace of a vial that has been heated and inject it into a GC split inlet.
Quantek Instruments Measure headspace oxygen in vials in less than 30 seconds Low-volume internal sensor for 1 to 250mL vials Ideal for quality monitoring of fill line accuracy To sample vials, use sampling probe to puncture headspace of vial septum.
Sampler, were designed to vent the pressurized vial to ambient pressure while fill-ing the sample loop. The Headspace Sampler introduced the use of onboard electronic pneumatics control to allow the headspace to control the final vial pres-sure seen in the sample loop during the sample loop filling process. Controlling this
Oct 2, 2015 · Genesis Packaging Technologies, for example, manufactures a Residual Force Tester that is used to measure the sealing force in pharmaceutical vials sealed with stoppers and aluminum caps. In analytical labs by comparison the most common test is a “twist-test”, in which the chemist attempts to twist the cap to determine if it is tight enough
Total gas concentration (TC) in the original water sample is calculated by determining the concentration of headspaceand converting this to the partial pressure and then solving for the aqueous concentration which partitioned in the gas phase (CAH) and the concentration remaining in the aqueous phase (CA). TC=CAH+CA{\displaystyle TC=C_{AH}+C_{A}}
Mar 29, 2023 · Container closure integrity testing methods can be deterministic or probabilistic: deterministic methods include helium leak testing, high voltage leak detection, laser headspace analysis, mass extraction, and pressure and vacuum decay methods; probabilistic methods include bubble leak and blue dye tests.